Results showed that EVO up-regulated the DNMT3A protein level in NSCLC cells, and it also increased the protein level of DNMT3B in H1299 cells (Figure 5C), suggesting that activation of the DNMTs-induced NOTCH3 methylation may be one of the mechanisms for EVO’s anti-NSCLC effects. The gene discussed is DNMT3A; the disease is non-small cell lung carcinoma.