MAPT and tauopathy: While these results explained the previously observed NAP interaction with microtubules, bringing into focus the SIP motif (Gozes et al., 2016; Quraishe et al., 2016) and suggesting an amplifier effect at the microtubule tip, the molecular mechanism of increased Tau hyperphosphorylation, as a consequence of ADNP deficiency and protection by NAP against tauopathy (Vulih-Shultzman et al., 2007; Matsuoka et al., 2008; Shiryaev et al., 2009; Jouroukhin et al., 2013), still required further investigations.