Future studies encompassing the impact of the NAP-EBs-Tau interaction on Tau aggregation (Gozes et al., 2014a,b), mitochondrial function (Esteves et al., 2014) and autophagy (Sragovich et al., 2017) are planned and will contribute to clarify the relevance of this protein complex in neuroprotection in the context of tauopathies and other neurodegenerative diseases. This evidence concerns the gene MAPT and tauopathy.