Importantly, as indicated, phosphorylation of S262 impaired EB/Tau interactions and our previous data have directly shown that NAP inhibits tau hyperphosphorylation at the S262 site (Jouroukhin et al., 2013) in multiple tauopathy models (Magen et al., 2014), with this phosphorylation site being linked to impaired axonal transport and neurodegeneration (Iijima-Ando et al., 2012), partially solving the NAP/ADNP protective activity against tauopathy (Figure 1). This evidence concerns the gene CTNNBL1 and tauopathy.