MAPK signaling pathway was also responsible for the ectopic expression of PD-L1 in v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant NSCLC cell lines, as revealed by the decrease in PD-L1 levels after both MEK and extracellular signal-regulated MAP kinase (ERK) abrogation [34]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.