GPT and anemia (phenotype): CTCAE grade ≥3 AEs causally related to AZD1208 occurred in 10 patients (28.6%): 240 mg, n = 3 (anaemia, alanine transaminase increased, GGT increased); 360 mg, n = 1 (lymphocyte decreased); 540 mg, n = 2 (vomiting, fatigue, lethargy); 700 mg, n = 1 (nausea, fatigue); 800 mg, n = 3 (fatigue, hyperglycaemia).