PIM1 and acute lymphoblastic leukemia: PIM kinases appear overexpressed in several tumour types, contributing to oncogenesis.5,6 For example, PIM1 is overexpressed in ~30% of haematopoietic malignancies, particularly in acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia.7 PIM1 in T cells induces the formation of lymphoma and increases the rate of lymphoma development in response to Murine Leukaemia Virus.6 Furthermore, PIM1 and PIM2 are overexpressed in haematological malignancies8,9 and solid tumours.9,10