SLC52A3 has been suggested as a potential therapeutic target.21 Knockdown of SLC52A3 in ESCC cells results in inhibition of cell proliferation, whereas overexpression of SLC52A3 in ESCC cells promotes cell proliferation and tumourigenesis in nude mice.21 Age is also an essential factor in the MASAN model as removing age resulted in declined predictive performance (Figure S6H and 6I). The gene discussed is SLC52A3; the disease is esophageal squamous cell carcinoma.