In subjects without NAFLD at baseline (n = 512), the BMI, WC, SBP, GGT, ALT, AST, TC, TG, FBG measurements and the prevalence of overweight, obesity, dyslipidaemia, hyper-TC, hyper-TG and hypo-HDL-C were increased significantly. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.