Furthermore, qRT-PCR validation in human bronchial epithelial cells 16HBE cells with and without CSE treatment, and in PBMC from donors and patients with COPD both shown that NR_102714 and its associated protein-coding genes UCHL1 presented the same expressional tendencies in 16HBE cells with CSE treatment, PBMC from patients with COPD and lung tissues of chronic CS-induced COPD mouse model. The gene discussed is UCHL1; the disease is chronic obstructive pulmonary disease.