Among these significantly differential expressed lncRNAs human homologues and mRNAs, 4 lncRNAs (fantom3_F830212L20, fantom3_7420409G12, NR_028593,NR_033450) human homologues and 6 mRNAs (NR1D2, PER3, HLF, AHRR, NQO1, SERPINA3) shown the common expressional tendencies in both 16HBE cells with CSE treatment and chronic CS-induced COPD mouse model when compared to control group. This evidence concerns the gene HLF and chronic obstructive pulmonary disease.