In the present study, high throughput data analysis revealed that 3 significantly differential expressed lncRNAs (NR_102714, fantom3_D330021G15 and fantom3_D830009E10) associated protein-coding genes (UCHL1,IL1RL1and GGT5) were both significantly differential expressed in patients with COPD and chronic CS-induced COPD mouse model when compared to control subjects. This evidence concerns the gene GGT5 and chronic obstructive pulmonary disease.