Among these significantly differential expressed lncRNAs human homologues and mRNAs, 3 lncRNAs (fantom3_C130011B08, fantom3_7420409G12, fantom3_D830009E10) human homologues and 6 mRNAs (NR1D2, NQO1, AHRR, GGT5, HSPA5, FKBP4) human orthologs shown the same expressional tendencies in both 16HBE cells with CSE treatment and chronic CS-induced COPD mouse model when compared to control group. Here, HSPA5 is linked to chronic obstructive pulmonary disease.