When genes were ranked according to fold changes between GC and normal gastric samples, ESRRG was one of top-ranked TFs and NRs, exhibiting a greater than 10-fold downregulation in cancer tissues (normal vs. tumor: -14.851 fold in GSE29272; -16.514 fold in GSE26899; -23.608 fold in GSE13861; Fig. 1b, Supplementary Fig. 1a and b). The gene discussed is ESRRG; the disease is cancer.