Indeed, our data demonstrate that the Wnt signaling-associated genes DVL3, LEF1, LGR5, TCF7L2/TCF4, AXIN2, and CTNNB1, were significantly downregulated by ESRRG in both GC cells and GC patient-derived organoid models (Figs. 4 and 6). Here, TCF7L2 is linked to gastric cancer.