The programmed cell death protein-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis is one of the major immune checkpoints identified to date in which binding of ligand PD-L1 (on antigen-presenting cells or cancer cells) to receptor PD-1 (on TILs) transmits inhibitory signals to suppress the activation, expansion, and acquisition of effector functions of TILs, especially CD8+ cytotoxic T cells1,2. The gene discussed is CD274; the disease is cancer.