In addition, in line with the effects of etoposide treatment (Fig. 6e), TOP2B silencing induced MET and downregulated STT3 and PD-L1 in spheres (Fig. 8d, left), resulting in reduced PD-1 binding (Fig. 8d, upper right) and sensitization of sphere cells to PBMC-mediated cancer cell killing in vitro (Fig. 8d, bottom right). This evidence concerns the gene CD274 and cancer.