In line with these observations, immunohistological inspection of WT1 expression in adult human myocardium from ARVC patients revealed a nuclear localization of WT1 protein in some of the CMs adjacent to the fibrofatty tissue, while only cytosolic‐localized protein could be detected in heart tissue samples from individuals lacking mutations in cell–cell junctional proteins (Fig EV4C and D). This evidence concerns the gene WT1 and Arrhythmogenic right ventricular dysplasia.