BMS-265246 restricted HIV-1 infection in MDM, whereas GW2580, a tyrosine kinase inhibitor (TKI) that targets colony-stimulating factor 1 receptor (CSF-1R) among other receptor tyrosine kinases (RTK), had no effect on viral infectivity (Fig. 5A) (28). The gene discussed is NTRK1; the disease is HIV-1 infection.