This is thought to propagate the transcriptionally inactive state of chromatin by K4me3 removal along the H3K4me3-enriched promoters.17, 18 KDM5A(PHD3) is implicated in acute myeloid leukemia (AML) and forms a fusion protein with nucleoporin protein 98 (NUP98), a common translocation partner.19 The gene discussed is KDM5A; the disease is acute myeloid leukemia.