TP53 and hereditary clear cell renal cell carcinoma: We also used network analysis to identify pathways common to the six profiles that were likely to be most important in PDAC, which led to 13 common core pathways (Fig. 2b): pathway in cancer, p53 signaling pathway, focal adhesion, cytokine–cytokine receptor interaction, regulation of actin cytoskeleton, glycolysis/gluconeogenesis, systemic lupus erythematosus, bladder cancer, small cell lung cancer, complement and coagulation cascades, ECM-receptor interaction, axon guidance, and renal cell carcinoma.