RAP1A and hepatocellular carcinoma: The depletion of EYA4 with shEYA4 significantly up-regulated the levels of RAP1A/RAP1 expression in HCC cells, but RAP1A/RAP1 expression and the shEYA4-mediated up-regulation of RAP1A/RAP1 were significantly hampered in cells treated with BAY 11-7085 (Fig. 4g, h).