For instance, in malignant peripheral nerve sheath tumors, EYA4 prominently sustains cell survival, migration and adhesion [18], and in contrast, emerging evidence implies that EYA4 is most likely a typical tumor suppressor that is epigenetically silenced in various tumors, such as esophageal adenocarcinoma [19], colorectal [20] and pancreatic cancer [21]. The gene discussed is EYA4; the disease is esophageal adenocarcinoma.