PDK1 and malignant colon neoplasm: Moreover, we noticed that, compared to PDK1 mRNA levels, blocking Wnt/β-catenin activity in colon cancer cells resulted in a further reduction in PDK1 protein levels [33], which suggests that post-transcriptional regulation of PDK1 by Wnt/β-catenin signaling at least partially contributes to the metabolism of colon cancer cells.