Accumulating evidence has demonstrated that the inhibition of Wnt/β-catenin by ZNRF3 [26], YPEL3 [27], SFRP1 [28], Wnt-C59 [29], SOX1 [30] and WIF-1 [31] in NPC cells was significantly compromised, resulting in elevated Wnt/β-catenin output levels. Here, SOX1 is linked to nasopharyngeal carcinoma.