The SCN1A genes encode nine mammalian voltage-gated sodium channel alfa subunits, and their mutation is one of the most common causes of epilepsy detected in 70% to 85% of patients with DS and 3% to 6% of patients with generalized epilepsy with febrile seizures plus (GEFS+) [91, 97–100]. This evidence concerns the gene SCN1A and Dravet syndrome.