Canonical correlation analyses showed that glioma-derived PTPN2 expression was positively correlated with the specific marker gene expression of all six immune cell types in both the CGGA and TCGA datasets [11] (Fig. 6, p < 0.001), which suggests that glioma tumors with high PTPN2 expression tend to have more infiltrating immune cells than gliomas with low PTPN2 expression. This evidence concerns the gene PTPN2 and central nervous system cancer.