Moreover, its corresponding top ten KEGG pathways are also encapsulated within cancer, metabolism, immune annotation (Fig. 7c), such as ‘Central carbon metabolism in cancer’ (P-value = 8.7e-04), ‘Insulin resistance’ (P-value = 4.6e-03), and ‘Intestinal immune network for IgA production’ (P-value = 6. Here, INS is linked to cancer.