The significant outcome of this study is the finding that differential transcript levels of FcGR1A and BATF2 and protein expression levels of IFNγ and CXCL10 robustly classified active TB in advanced HIV, including the 3 HIV-infected and 5 TB-HIV individuals whose gene expression pattern was not consistent with their fellow members. The gene discussed is CXCL10; the disease is tuberculosis.