EGF and breast carcinoma: To determine whether atorvastatin would influence the EGF responsiveness of our breast cancer cell lines, we treated MCF-7 RFP, MDA-MB-231 RFP, and MDA-MB-231 RFP/Ecad with atorvastatin for 24 hours and then stimulated with 5nM EGF for 5 or 30 minutes.