Similar to our previous observation that CD93 expression is increased in the vasculature of human high-grade glioma (HGG) (11), MMRN2 and fibronectin were significantly elevated in WHO grade III and IV glioma compared with low-grade glioma (LGG; WHO grade II) or control brain samples (Figure 9, C and D). This evidence concerns the gene FN1 and glioma.