Comparison between the low‐pathological H3N2 X31 strain and the high‐pathological H1N1 PR8 strain show that a more robust CD8+ T cell response is generated upon infection with the X31 influenza virus and is paired with higher levels of IL‐12 in the microenvironment and more IFN‐γ production by CD8+ T cells 41. The gene discussed is CD8A; the disease is infection.