This has potential associations with the mechanisms of cell death in UC , as deficiencies in commensal-induced pyroptosis has been shown to increase the severity of UC in a murine model.31 Variable TUBB6 expression has also been seen in other malignancies such as nonsmall cell lung cancer32 and prostate, ovary, and breast cancer.33 Some evidence has been demonstrated in cell lines by Mariani et al34 that TUBB6 expression is partially controlled by androgen receptor status, with women showing higher expression of TUBB6 than men. This evidence concerns the gene TUBB6 and breast cancer.