A proteomics study by Yang et al. [55] of induced pluripotent stem cells-derived RPE (iPSC-RPE) from AMD patients with high-risk, single-nucleotide polymorphism (SNP) at the ARMS2/HTRA1 locus and non-AMD controls demonstrated that in vitro treatment with the bis-retinoid A2E, a major component of lipofuscin, and exposure to blue light elicits a large increase in protein expression of the anti-oxidant superoxide dismutase 2 (SOD2) enzyme only in iPSC-RPE cells derived from non-AMD controls. Here, HTRA1 is linked to age-related macular degeneration.