CRP and Crohn disease: A large body of literature has demonstrated that EPA and DHA reduce plasma concentrations of inflammatory cytokines.15 In clinical trials, fish oil supplementation has been associated with symptom relief and reductions in serum levels of proinflammatory cytokines in persons with rheumatoid arthritis and asthma,16–18 reduced plasma C-reactive protein (CRP) and IL-6 levels in persons with pancreatitis,19 and reduced flares in persons with Crohn's disease.20 Both the dose and duration of fish oil tested in randomized clinical trials (RCTs) have been highly variable.