To evaluate whether PD‐L1 overexpression in the tumor might have a prognostic value in HNSCC, dividing patients in high (>125 FPKM) and low (<125 FPKM) CD274‐expressed levels from TCGA database revealed that the high CD274 mRNA expressing group had a significantly reduced 5‐year survival rate (Figure 1A). This evidence concerns the gene CD274 and neoplasm.