CD274 and neoplasm: This poor reaction to chemotherapy was supported by the evidence that the PD‐L1/PD‐1 immune checkpoint might confer tumor cell chemoresistance, and blockade of PD‐L1/PD‐1 limited chemoresistance of malignancy.24 PD‐L1 molecular can be found expressed in both tumor cells and tumor‐infiltrating immune cells in the tumor.