LfcinB can selectively kill many types of tumor cells through targeting the cell membrane and conquering multidrug‐resistance, including HNSCC cells.9, 10, 11 Our results indicated that one possible mechanism of LfcinB is to break down the drug resistance of tumor cells through down‐regulation of IL‐6 and PD‐L1. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.