From an assessment of PD‐L1 in tumor cells and immune cells in HNSCC, the high PD‐L1 expression in immune cells instead of tumor cells is a favorable prognostic factor for HNSCC resection.25 PD‐L1 expression in HNSCC xenografts and its immunological mechanism is going to be investigated in the further studies. Here, CD274 is linked to head and neck squamous cell carcinoma.