To investigate whether MAPK signalling is deregulated in gastric cancer, we examined the expression of SPAG9 and downstream effectors of MAPKs, such as c‐Jun, phosphorylated (p)‐Jnk, p‐p38 and p53, by immunohistochemistry in gastric cancer tissues and paired normal gastric tissues (n = 48). The gene discussed is SPAG9; the disease is gastric cancer.