HBeAg through its precore‐specific sequence binds to the Toll/IL‐1 receptor (TIR) motif to stop TLR signaling that induced by TLR2 or TLR4 ligands.34, 35 It is known that HSC and Kupffer cells express TLR4 which makes them sensitive to LPS.15 TLR4 signaling is a significant mediator of hepatic fibrosis in quiescent HSC by expression of proinflammatory factor‐kappa B (NF‐kB) factor in downstream of TLR4 activation.36 Here, TLR4 is linked to Hepatic fibrosis.