Growing studies indicated that lncRNAs acted crucial roles in several biological processes by playing as ceRNAs (competing endogenous RNAs) or molecular sponges to modulate‐specific miRNAs.34, 37, 41, 42, 43 Previous study showed that HOXA11‐AS functions as an oncogenic gene which enhanced glioma cell metastasis and growth by inhibiting miR‐214‐3p/EZH2 expression.39 In this regard, we also found that ectopic expression of HOXA11‐AS suppressing the miR‐214‐3p expression in the HCC cell. Here, EZH2 is linked to central nervous system cancer.