Among them, more than two‐thirds (67.8%) were frame shift mutations which resulted in proteins with extended C‐terminus and induced peptidyl‐tyrosine modification and cancer progression.48 It was also reported that mutations of GATA3 in breast cancer cells were related to reduced DNA binding ability and increased cell proliferation, resulting in endocrine resistance.49, 50 We found that the old patients had much less frame shift mutations in GATA3 than young patients, which may be the reason that GATA3 mutations had no effects on the associations between age and prognosis of breast cancer. The gene discussed is GATA3; the disease is cancer.