Aging may to some extent explain the reasons why the prognosis was worse for older patients but not for younger patients.6, 7 It was reported that this age disparity in breast cancer survival can be explained by pathologic factors such as hormone receptor status or treatment.8, 9, 10, 11 However, the disparity remains even under control of the clinicopathologic features, treatments, or comorbid conditions.12, 13, 14 Therefore, the reasons for the survival disparity of breast cancer need exploration, particularly for the young patients. Here, NR4A1 is linked to breast cancer.