Notably, IRX5 is enhanced in colorectal cancer and human adenomas,15, 16 and IRX5 silencing inhibited LNCaP prostate cancer cell apoptosis.17 However, although several studies regarding the connection of IRX5 with cancer have been reported, the accurate functions of IRX5 in the progression and suppression of TSCC remains largely indistinct. This evidence concerns the gene IRX5 and colorectal cancer.