Previously, we showed that treatment of ABC294640 led to down‐regulation of Mcl‐1 and c‐Myc expression via proteasome degradation in MM cells.4 To analyze the mechanism underlying the synergy of ABC294640 and ABT‐199, we investigated the changes of Bcl‐2 family members after combination treatment. Here, BCL2 is linked to Miyoshi myopathy.