CCND1 and plasma cell myeloma: Translocation (11;14) results in a dysregulated cyclin D1 expression under the transcription control of immunoglobulin heavy chain and an accelerated G1 to S phase transition.37 Patients with a t(11;14) translocation only account for 15‐20% of all myeloma patients,38, 39, 40 and single agent ABT‐199 has very limited activity on myeloma cells without the translocation.