We have demonstrated that SK2 is overexpressed in MM cell lines and in human MM specimens.4 ABC294640 (YELIVA®) [3‐(4‐chlorophenyl)‐adamantane‐1‐carboxylic acid (pyridin‐4‐ylmethyl) amide, hydrochloride salt] is an orally available inhibitor of SK2.4 Inhibition of SK2 by RNA interference or treatment with ABC294640 effectively promotes apoptosis in MM cell lines and inhibits the proliferation of primary human myeloma cells. The gene discussed is SPHK2; the disease is plasma cell myeloma.