We selected an SK2 inhibitor, which we have previously shown can promote proteasomal degradation of c‐Myc and Mcl‐1 and induce caspase‐mediated apoptosis in MM cell in vitro and in vivo.4 In the present study, we showed ABC294640 can also down‐regulate Bcl‐xL in MM cell lines. This evidence concerns the gene MYC and Miyoshi myopathy.