We selected an SK2 inhibitor, which we have previously shown can promote proteasomal degradation of c‐Myc and Mcl‐1 and induce caspase‐mediated apoptosis in MM cell in vitro and in vivo.4 In the present study, we showed ABC294640 can also down‐regulate Bcl‐xL in MM cell lines. The gene discussed is MCL1; the disease is Miyoshi myopathy.