BAX and Miyoshi myopathy: However, the cleavage of Bax does not imply a decrease in pro‐apoptotic function because previous studies have shown that the cleavage of Bax and Bid is mediated by caspase‐dependent processes, and the cleaved Bax and Bid were associated with increased mitochondrial‐mediated apoptotic pathway.62, 63 To further support this rationale, we performed the mitochondrial membrane potential (MMP) assay in MM cells, and showed ABC294640 does not induce mitochondrial membrane damage, whereas ABT‐199 reduces mitochondrial membrane potential (Figure 6).