Previously, we showed that treatment of ABC294640 led to down‐regulation of Mcl‐1 and c‐Myc expression via proteasome degradation in MM cells.4 To analyze the mechanism underlying the synergy of ABC294640 and ABT‐199, we investigated the changes of Bcl‐2 family members after combination treatment. This evidence concerns the gene MCL1 and Miyoshi myopathy.