SATB2 may act as a master regulator of pluripotency and self‐renewal because SATB2 binding sites are present in the promoter regions of KLF4, Oct4, cMyc and Sox2.45, 46, 47, 48 Similar to pancreatic CSCs, we have found that SATB2 is highly expressed in colorectal and breast CSCs.24, 30 Interestingly, the expression of SATB2 was absent or very low in HPNE cells, mammary epithelial cells and colorectal epithelial cells.20, 24, 30 Furthermore, overexpression of SATB2 in normal epithelial cells resulted in malignant transformation, suggesting an oncogenic role of SATB2 in various cancers. The gene discussed is KLF4; the disease is cancer.