HSPB6 and heart failure: We have recently identified a human mutation in the Hsp20 gene, which results in an amino acid change from serine to phenylalanine at position 10 (S10F).8 Transgenic (TG) male mice with cardiac overexpression of this mutation presented with impaired autophagy and increased apoptosis at an early age, resulting in cardiac dysfunction, heart failure and reduced survival.8 These findings prompted us to examine the role of the human S10F‐Hsp20 mutation in females and specifically its effects on cardiac function and remodelling upon pregnancy.