Activated platelets in patients with dengue or platelets infected with DENV in vitro secrete various factors with vasorelaxing or endothelial activating functions, including small molecules (serotonin and nitric oxide) (153, 198, 199), granule-stored chemokine (RANTES/CCL5 and PF4/CXCL4) (154), and newly-synthesized IL-1β (26). The gene discussed is PF4; the disease is dengue disease.