Even through platelets internalize HIV-1 viral particles though similar mechanisms involving DC-SIGN or C-type lectin-like receptor 2 (CLEC-2) for viral attachment (14, 57), it is still controversial if platelets can perform HIV-1 trans-infection to T cells, and opposite results have been found on this regard (14, 61), as will be discussed in Section “Platelet Activation in HIV Infection.” The gene discussed is CLEC1B; the disease is infection.