Although the role of TGF-β has not yet been fully defined in this EMT-like process, in vitro experiments have demonstrated that the ability of TGF-βs to promote this EMT-like phenomenon (63) may be associated with the pro-migratory effect of TGF-β1 on several osteosarcoma cell lines (50, 64–66). Here, TGFB1 is linked to osteosarcoma.