Tumor-associated stroma mainly consists of two major categories of component: (i) the extracellular matrix, composed of structural proteins such as collagen and elastin, specialized proteins such as fibronectin, and proteoglycans such as hyaluronan; (ii) cellular elements, composed of cells surrounding the tumor tissue that play a part in the stromal response, i.e., bone cells, vasculature and endothelial cells, pericytes, immune cells such as macrophages [tumor-associated macrophages (TAMs)] and lymphocytes, and mesenchymal stromal cells (MSC). Here, ELN is linked to neoplasm.