The results obtained in this study are consistent with those reported for A2AR antagonists that reverted the anhedonia‐like (loss of interest or pleasure) condition in OBX rats, which is the main depression diagnostic criteria (DSM‐V) and is consistent with previous studies (Kaster et al., 2015) and escitalopram treatment (Kurhe, Mahesh, Gupta, & Devadoss, 2014). Here, ADORA2A is linked to major depressive disorder.