Treatment of ALK-driven NB cells with Nutlin-3 induced cell-cycle arrest, but not cell death, similar to that seen with ALK inhibitors (Figs. 3a, b and 4a, b; Supplementary Figure 2e); in contrast, combination of the ALK inhibitors with either Nutlin-3 or RG7112 effectively induced cell death in ALK-driven NB cells (Figs. 3a, b and 4a, b; Supplementary Figure 2a, 2b). Here, ALK is linked to neuroblastoma.