Moreover, dihydropyridine compounds with good central nervous system (CNS) penetration, such as nimodipine showed promising mood stabilizing effects in humans with affective disorders, suggesting that LTCC antagonists represent an additional option in the pharmacotherapy of psychiatric diseases, and especially patients carrying the CACNA1C risk SNP could benefit from this alternative treatment strategy13,43,52. The gene discussed is CACNA1C; the disease is psychiatric disorder.