INS and Hypoglycemia: Similarly, Khunti et al. [14] found that the suboptimally controlled group (HbA1c ≥ 53 mmol/mol [7%]) treated with once-daily insulin detemir in the SOLVE trial had a relatively low risk of hypoglycemia and suboptimal FBG levels at 24 weeks, which according to the authors suggested that ‘a more aggressive titration regimen could be implemented to improve glycemic control’.