For people with newly diagnosed T2DM who are symptomatic and/or have highly elevated levels of glycated hemoglobin (HbA1c) (≥ 86 mmol/mol [≥ 10%]) and/or blood glucose (BG) (≥ 16.7 mmol/L [≥ 300 mg/dL]), basal-bolus insulin (preferred if symptomatic) or basal insulin plus a glucagon-like peptide-1 receptor agonist (GLP1-RA) should be considered for initial treatment [1]. The gene discussed is INS; the disease is type 2 diabetes mellitus.