C-reactive protein (CRP), an acute-phase protein secreted by the liver in response to interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α [13], is a well-characterized marker of inflammation, and increased circulating levels have been shown to be associated with obesity and increased metabolic risk [14]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.