IL6 and periodontitis: IL-6 -174G genotype has been found to be associated with Aggregatibacter actinomycetemcomitans in generalised aggressive periodontitis patients and with both Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in IL-6 -174GG and IL-6 -6106AA polymorphisms [68, 69].