So, the alteration in a single gene can influence the various cytokines by altering dominated arm of immune response as seen for the levels of IL-4 and IL-13 which are influenced by IL-4 receptor complex specially the IL-4RA Q551R and associated with diseases such as the Hyper-IgE syndrome, Atopic dermatitis, Asthma, Systemic lupus erythematosus (SLE), Sjörgren syndrom, Systemic scleroderma, and Cutaneous mastocytosis, where an allergic or autoimmune pathogenesis is assumed [51]. Here, IL4 is linked to systemic lupus erythematosus.