Among the rare conditions, the IL-10 SNPs has been analysed in renal transplant patients with cyclosporine-A induced gingival overgrowth in a Chinese population and found to be associated with the higher prevalence of Porphyromonas gingivalis and Treponema denticola especially in subjects with ATA haplotype [78]. The gene discussed is IL10; the disease is gingival overgrowth.