For example, resveratrol ameliorated DSS-induced acute inflammation in mouse colonic mucosa through inhibition of iNOS expression and NF-kB, signal transducer and activator of transcription-3 (STAT3) and extracellular signal-regulated kinase (ERK) activity [55] demonstrated that oral administration of resveratrol ameliorated established chronic colitis in IL-10 (-/-) mice by inducing immunosuppressive CD11b(+) Gr-1(+) myeloid-derived suppressor cells (MDSCs) in the colon.. Here, STAT3 is linked to Chronic colitis.