TP53 and malignant colon neoplasm: Another interesting study suggests that cotreatment of curcumin and resveratrol was more effective than either agent alone in inhibiting the growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells [36].