We found all exogenous tissue kallikrein treatments starting at 8 h, 24 h, and 36 h (i.e., KLK 8 h, KLK 24 h, and KLK 36 h) after ischemic stroke can ameliorate the neurological deficits, but the KLK 8 h group has lower scores (better neurological outcome) than the KLK 24 h and KLK 36 h groups (Figures 1(b)–1(d)). Here, KLK4 is linked to ischemic stroke.