In recent years, significant attention has been drawn to the fact that esg is expressed in stem cells in several tissues, including intestinal stem cells (ISCs), cyst stem cells and male germline stem cells and is a primary component of testis stem cells (Loza-Coll et al., 2014; Voog et al., 2014; Loza-Coll and Jones, 2016). Here, TLE2 is linked to cyst.