HLA-C*06:02 further shares the strong negative charge of the E-pocket with HLA-C*12:03 (44) which has several similar functional domains and peptide-binding pockets as HLA-C*06:02 (46) and constitutes another potential HLA-risk allele for psoriasis and psoriatic arthritis (20, 23). Here, HLA-C is linked to psoriasis.