In summary, presence of complement fragments on HIV’s surface modulated responses in DCs and their cross talk with NK cells to inhibit killing and to promote the upregulation of factors associated with immune suppression (PD-1, TIM-3, LAG-3) and susceptibility to infection (TCM, CD38, CXCR3, CCR4) on CD4 T cells. Here, PDCD1 is linked to infection.