Both WCHABP1 and WCHABP12 had 10 genes involving in genome replication, transcription, establishment of infection, and other processes, including a RNA polymerase, a DNA helicase, a transcriptional regulator, a fis family transcriptional regulator, an ERF (essential recombination function) family protein, a nucleoside triphosphate pyrophosphohydrolase, a HNH endonuclease, an endodeoxyribonuclease, a superinfection immunity protein and a bacteriophage antirepressor protein (Table 2). The gene discussed is ERF; the disease is infection.