KISS1R and triple-negative breast carcinoma: Recently, KiSS-1R has been documented to induce invasion of triple negative breast cancer (TNBC) cells which lack ERα, progesterone receptor, and human epidermal growth factor receptor 2; also, KiSS-1 mRNA and KiSS-1R mRNA and protein were found to be upregulated in TNBC tissues as compared to normal breast tissue (25).