SIRT1 and neoplasm: Through human tumor metastasis PCR array, Shen et al. identified KiSS-1 as one of the downstream targets of SIRT1: silencing of SIRT1 upregulates KiSS-1 expression by enhancing the acetylation of the transcription factor CREB which, in turn, may be activated through its binding to the promoter of KiSS-1.