In the AD brains, SET is translocated from its primary nuclear location to the cytoplasm in the neurons and co-localizes with both PP2A and abnormally hyperphosphorylated tau which forms NFTs in the neuronal cytoplasm (Tanimukai et al., 2005; Tsujio et al., 2005; Polydoro et al., 2013). This evidence concerns the gene MAPT and Alzheimer disease.